The position provides skilled medical technology and histology capabilities to support the scope of the pathology and histology services, and the research related functions and goals of the Histopathology Laboratory in the Lombardi Cancer Center. Duties include daily processing and sectioning of tissue sections and identification and immunohistochemical staining of patient research samples for support of biomarker discovery and validation projects for translational research studies as well as animal model research studies. This position encompasses and provides technical and pathology support to all three departmental sub-divisions of the Histopathology and Tissue Shared resource. The position reports directly to both HTSR Co-Directors and provides mentorship and training to personnel. Duties include but are not limited to:
Performs specific bench work for basic and clinical research to perform biochemical, molecular biology, serological, microscopic, bacteriological examinations and assays of biological samples.
Performs complex database searches to identify samples appropriate for translational research study.
Manages and conducts technical aspects of assigned projects, development of laboratory protocols and procedures, preparing concept proposals and grant applications, training research staff and users of the facility.
Prepares billing for completed work to ensure proper payment for services provided. These functions are performed in accordance with Georgetown University Medical Centers policies, procedures and standards.
Designing and construction of tissue microarrays. Performs molecular assays like microRNA in situ hybridization, immunohistochemistry and multiplex staining. Provides training to laboratory personnel and users.
Manages all technical aspects of experimental design for conducting assigned projects. Performs microtomy, staining, tests, assays and procedures appropriate to the project(s), following specific protocols. Develops and adjusts protocols as necessary to accomplish goals. Problem-solves. Performs special histological stains as applicable to unique projects. Processes frozen tissue samples including grossing, trimming, embedding, sectioning and staining.
Provides pathology knowledge and support to Human Tissue Bank by reviewing the potential tissue samples and pathological reports appropriate for the projects. Identifying patients by chart review and selection of blocks as well as respective review of slides for the projects.
Contributes to the authoring of publications and presentations. Performs imaging for data collection and manuscript preparation. Performs literature searches and investigations. Keeps abreast of current literature. Prepares concept proposals for future projects under the direction of the Director of the Molecular Pathology Laboratory.
Assumes other duties and responsibilities that are appropriate to the position and area and as directed by the Director of the Molecular Pathology Laboratory. Orders and inventories laboratory supplies.
Maintains accurate records to fulfill requirements of SOPs for multiple specific and unique projects.
1 to 3 years of related experience (research/medical/clinical)
Excellent organizational and communication skills and ability to work independently as well as collaboratively with investigators
Minimally B.S. but preferably Master’s degree in related field
Internal Number: JR05621
About Georgetown University Medical Center
The Histopathology & Tissue Shared Resource (HTSR) is Georgetown Lombardi's resource for accessing human tissue for translational research and provides comprehensive, high quality laboratory and interpretive pathology services. The HTSR consents for, collects and distributes fresh- and formalin-fixed paraffin embedded tissue as well as provides technical and pathological support for investigator-driven collection protocols including the novel conditionally reprogrammed cells program. The HTSR also coordinates with the company Indivumed for the collection of high-quality biospecimens including matching fresh frozen and formalin fixed tissues, serum, plasma, urine and comprehensive clinical data. HTSR Co-Director Brent Harris, MD, PhD, provides comprehensive pathology services with a speciality in neuropathology. Under the direction of HTSR Co-Director Deborah Berry, PhD, the Histopathology Laboratory provides comprehensive histology services including necropsy, tissue processing, microtomy, staining, immunohistochemistry, laser capture micro-dissection and tissue microarray construction, staining and high-throughput analysis. In addition, the HTSR provides expert technical support, consultation services and educational support and training for users.