A postdoctoral Research Fellow position is available to join the lab of Drs. Francesco T. Mangano and June Goto in the Division of Pediatric Neurosurgery. The lab investigates neural cell development and neuroinflammation using several rodent models of neonatal hydrocephalus and applying molecular neurobiological approaches, such as CRISPR/Cas9 genome editing, adeno-associated virus, confocal microscopy, and single nuclear-RNA sequencing. The position offers an opportunity to engage in National Institute of Health-funded projects and according to the candidate's substantive research interests/background. The team is currently investigating genetic etiology and novel therapeutic methods targeting brain myeloid cells (microglia and CNS macrophages), choroid plexus, and ependymal cells for improving neurodevelopmental outcomes of neonatal hydrocephalus. Please see https://www.ncbi.nlm.nih.gov/myncbi/june.goto.1/bibliography/public/ for publications. Responsibilities include analyzing biochemical, histological, brain MRI, and gene expression data, presenting at national/international conferences, internal research seminars, and Journal Club, and writing research manuscripts and fellowships.
MAJOR DUTIES AND RESPONSIBILITIES:
Design, execute, and record laboratory experiments, and analyze the data.
Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.
Present research at laboratory meetings, journal clubs, seminars, and meetings.
Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
Maintain currency in field through continuing education, literature, and seminars.
Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures.
Perform other duties as assigned.
Cincinnati Children's Research and Training at a Glance
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
Ph.D. in related discipline, MD, DO, or equivalent required. (or an anticipated Ph.D. or M.D. completion by June 2023)
Basic research experience with molecular biology, neuroscience, immunology, MRI, computer science, or a related field
Ability to work independently with general supervision and as part of a team
Experience working with genetic/disease models
Knowledge of developmental brain disorders
Ability to stay current with research topics.
PREFERRED: Experience with animal surgery, MRI data analysis skills, gene mutation database analysis skills, confocal microscope skills, experience with mouse genetics, or experience with large-scale data handling.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.